REWIND
Quercetin 250 mg, trans-resveratrol 150 mg, and NAD+ 500 mg per two-capsule serving.*
90-Day Guarantee
Try it for 90 days. If it isn't right, we'll refund the unused portion — no return shipping, no hassle.
Inside REWIND
Two polyphenols, studied together*
A 26-week double-blind placebo-controlled trial in healthy overweight older adults studied resveratrol and quercetin taken in combination.*
Full label transparency
Every dose printed on the label. No proprietary blends.
Standardized extracts*
Quercetin from Sophora japonica flower bud. Trans-resveratrol standardized to 98% from Japanese knotweed root.*
THE RITUAL
Two capsules. Every morning.
Take two capsules with 6-8 oz of water, with or without food.
Human trials of resveratrol and quercetin have run from 8 weeks to 26 weeks.
How It Works
Three compounds, three roles.
Quercetin is a plant flavonoid studied for antioxidant activity. Trans-resveratrol is a polyphenol found in Japanese knotweed and red wine.
Nicotinamide adenine dinucleotide is a coenzyme present in every living cell, where it participates in energy metabolism and enzyme function.*
THE FORMULA
Vegan · Gluten Free · Non-GMO · Manufactured in a GMP-certified, FDA-registered facility in the USA.
The Research
Human evidence
A 26-week randomized, double-blind, placebo-controlled trial in 46 healthy overweight adults aged 50 to 75 studied 200 mg/day resveratrol combined with 320 mg/day quercetin and reported improved memory retention and glucose metabolism. (Witte AV, Kerti L, Margulies DS, Floel A. J Neurosci 2014;34(23):7862-7870. PMID 24899709)
A meta-analysis of 7 trials in 587 patients found quercetin significantly reduced systolic and diastolic blood pressure, with the effect reaching significance at doses of 500 mg per day or above. (Serban MC, Sahebkar A, Zanchetti A, et al. J Am Heart Assoc 2016;5(7):e002713. PMID 27405810)
What the evidence does not show
A subsequent trial in adults with mild cognitive impairment did not reproduce the memory finding. Human pharmacokinetic data indicate quercetin does not increase resveratrol absorption. There is no published human trial demonstrating that orally administered NAD+ raises NAD+ levels.
These studies tested the ingredients at their studied doses, not REWIND.*
FAQ
What people ask about REWIND
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Each two-capsule serving provides 500 mg nicotinamide adenine dinucleotide, 250 mg quercetin dihydrate extract from Sophora japonica, and 150 mg Japanese knotweed extract standardized to 98% trans-resveratrol.
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Quercetin is a flavonoid found in onions, apples, capers, and Sophora japonica flower buds. It has been studied in human trials for antioxidant activity, blood pressure, and exercise performance.
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Trans-resveratrol is a polyphenol present in red wine, grapes, and berries. Japanese knotweed root is the most concentrated commercial source, which allows standardized extraction to 98% purity rather than relying on variable plant content.
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Human trials have used resveratrol from roughly 100 mg to 5 g daily and quercetin from 150 mg to 1,000 mg daily, over periods from a few weeks to six months.
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Quercetin and resveratrol have both been studied in human trials without a consistent pattern of serious adverse effects. Some people report mild digestive discomfort or headache.
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Resveratrol may affect blood pressure, blood glucose, and platelet activity. Anyone taking anticoagulant, antihypertensive, or antidiabetic medication should consult a qualified healthcare professional. Not studied in pregnancy or breastfeeding.
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Yes. They are formulated to be taken together as part of a daily routine. Take both in the morning with water.
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SIGNAL provides 500 mg of beta-nicotinamide mononucleotide, a precursor cells use to synthesize NAD+. REWIND provides NAD+ itself alongside two studied polyphenols, quercetin and trans-resveratrol.
90-Day Guarantee
Try it for 90 days. If it isn't right, we'll refund the unused portion — no return shipping, no hassle.