SIGNAL YEAR ONE — 12-Month Supply

Twelve months of SIGNAL. One payment. No auto-renew.
Not ready for a year? Subscribe monthly at $35.99 and skip, pause, or cancel anytime. See SIGNAL
Regular price $379.00 Sale price $539.88
Unit price per

90-Day Guarantee

Ninety days to decide. Photograph whatever is still sealed and we refund those months at $31.58 each. Nothing ships back.

  • GMP Facility
  • Made in USA
  • 90-Day Guarantee

Twelve months of SIGNAL. Twelve bottles, one shipment, one payment.

Each capsule provides 500 mg of β-nicotinamide mononucleotide, a precursor cells use to synthesize NAD+.*

$379 for the year. Buying twelve bottles separately costs $539.88.

No auto-renew. Your card is charged once.

A year in one box:

  • 12 bottles of SIGNAL, delivered together.

$1.04 per day:

  • $379 for twelve months.

Charged once:

  • One payment. No auto-renew, no subscription to cancel.

Ninety days to decide:

  • Photograph what is still sealed and those months are refunded at $31.58 each.

What Arrives

Three SIGNAL supplement bottles floating at angles against a light background

  • 12 bottles, one shipment

    A full year of SIGNAL on the counter, not a subscription to manage.

  • $1.04 per day

    $379 for the year. Subscribe & Save costs $431.88 a year.

  • Your card is charged once

    No auto-renew. No recurring charge. No cancellation to remember.

THE RITUAL

One capsule. Every morning. For a year.

Take one capsule with 6-8 oz of water, with or without food.

Each bottle is a 30-day supply. Open the next one when the last runs out.

Why a Year

Consistency is the variable that matters.

The human trials behind NMN ran 8 to 12 weeks. Every one of them measured daily use over months, not occasional use.

The most common reason a supplement routine fails is that it runs out and does not get reordered.

SIGNAL YEAR ONE removes that failure point. The year is already on the shelf.

THE FORMULA

One active ingredient. No guessing.

β-Nicotinamide Mononucleotide (β-NMN) — 500mg
The direct cellular precursor to NAD+. This is the molecule researchers at Washington University School of Medicine, Harvard Medical School, and Keio University have studied in human trials.* No proprietary blend. No hidden dose. The full 500mg is listed in the name.

HPMC — Vegetable Capsule
Plant-derived, vegan. No gelatin, no animal byproducts.

Microcrystalline Cellulose · Silicon Dioxide · Magnesium Stearate
Standard functional excipients required for capsule manufacturing integrity. Included because the capsule needs them.

What you won't find:
No artificial colors · No artificial flavors · No gluten · No lactose · No allergens · No antibiotics · No hormones · No alcohol

Certifications:
Vegan · Gluten Free · Lactose Free · Allergen Free · Halal · Manufactured in a GMP-certified, FDA-registered facility in the USA.

The Research

The evidence

A 2024 meta-analysis of 12 randomized controlled trials covering 513 participants found a significant overall effect of oral NMN supplementation on blood NAD+ levels. (Zhang J, Poon ETC, Wong SHS. Crit Rev Food Sci Nutr 2025;65(22):4382-4400. PMID 39116016)

In a randomized, double-blind, placebo-controlled trial, 250 mg/day of NMN for 12 weeks in older adults produced significantly higher blood NAD+ and a significantly shorter 4-metre walking time versus placebo. (Morifuji M, Higashi S, Ebihara S, Nagata M. GeroScience 2024;46(5):4671-4688. PMID 38789831)

A multicenter dose-ranging trial in 80 healthy middle-aged adults tested 300, 600, and 900 mg daily for 60 days. All doses raised blood NAD+. (Yi L, Maier AB, Tao R, et al. GeroScience 2023. DOI 10.1007/s11357-022-00705-1)

These studies tested the ingredient, not SIGNAL YEAR ONE.*

FAQ

What people ask about SIGNAL YEAR ONE

  • Twelve bottles of SIGNAL in one shipment, 30 capsules each. A full twelve-month supply.

  • No. One payment of $379. Your card is charged once and not again. There is nothing to cancel.

  • Subscribe & Save costs $431.88 a year. SIGNAL YEAR ONE is $379, or $1.04 per day — a saving of $52.88.

  • You have 90 days. Photograph whatever is still sealed and those months are refunded at $31.58 each. Nothing needs to ship back.

  • Yes. Every bottle is dated and the full supply is within date on arrival. Store sealed bottles in a cool, dry place.

  • The human trials behind NMN measured daily use over weeks. The most common reason a routine fails is running out and not reordering.

  • This is SIGNAL only. Protocol YEAR ONE includes both SIGNAL and REWIND for twelve months at $697.

  • NMN has not been studied in pregnancy, breastfeeding, or in people under 18. Anyone taking prescription medication, managing a medical condition, or scheduled for surgery should consult a qualified healthcare professional.

90-Day Guarantee

90-Day Guarantee

Ninety days to decide. Photograph whatever is still sealed and we refund those months at $31.58 each. Nothing ships back.

*Statements on this website have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. If you are taking prescription medication, have a medical condition, or are pregnant or nursing, consult your physician prior to use. Not for children. Results may vary.